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A normal hormone range can also vary with advancing age

The above insights are being tested in a clinical trial (NCT04107311) that aims to prospectively investigate the role of the intestinal microbiome and autoimmune panels as predictors of Grade 2 irAEs requiring immunosuppression

However, due to the variety of DAMPs and the complex mechanism of action, the research on inhibitors of DAMPs release is still in the primary stage